学会発表
1. 永淵正法、Rasheda Perveen、三根敬一朗、皆川洋子、森仁恵、高橋宏和、安西慶三. ウイルス糖尿病発症機構の総合的解析：ウイルス受容体、Tyk2, Stat2　遺伝子の意義.
日本感染症学会学術講演会　2025年5月4日
2. Rasheda Perveen, Seiho Nagafuchi, Keiichiro Mine, Hitoe Mori, Keizo Anzai,, Hirokazu Takahashi. Coxsackie B virus developed diabetes in β-cell specific virus receptor positive Stat2 knockout mice. 日本糖尿病学会学術講演会　2025年5月30日

原著
1._Mine K, Nagafuchi S, Anzai K, et al. Tyk2-mediated signaling promotes the development of autoreactive CD8+ CTLs in type 1 diabetes. Nat Commun 15(1):1337, 2024.
2._Jimbo E, Kobayashi T, Mine K, Nagafuchi S, Anzai K, et al. Immunohistochemical detection of enteroviruses in pancreatic tissue of patients with type 1 diabetes using a polyclonal antibody against 2A protease of coxsackievirus. J Diabetes Investig 13(3):435-442, 2022.
3. Mori H, Takahashi H, Mine K, Nagafuchi S, Anzai K, et al. TYK2 promoter variant is associated with impaired insulin secretion and lower insulin resistance in Japanese type 2 diabetes patients. Genes 12(3):400, 2021.
4. Mine K, Nagafuchi S, Takahashi H, Anzai K, et al. Impaired upregulation of Stat2 gene restrictive to pancreatic β-cells is responsible for virus-induced diabetes in DBA/2 mice. Biochem Biophys Res Commun 521(4):853-860, 2020.
5. Mine K, Hirakawa K, Nagafuchi S, Anzai K, et al. Subtyping of type 1 diabetes as classified by anti-GAD antibody, IgE levels, and tyrosine kinase 2 (TYK2) promoter variant in the Japanese. EBioMedicine 23:46-51, 2017.
6. Nagafuchi S, Kamada-Hibio Y, Anzai K, et al. TYK2 promoter variant and diabetes mellitus in the Japanese. EBioMedicine 2:744-749, 2015.
7./Izumi K, Mine K, Nagafuchi S, Anzai K, et al. Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes. Nat Commun 6:6748, 2015.
8. Kounoue E, Izumi K, Ogawa S, Kondo S, Katsuta H, Akashi T, Niho Y, Harada M, Tamiya S, Kurisaki H, Nagafuchi S. The significance of T cells, B cells, antibodies and macrophages against encephalomyocarditis (EMC)-D virus-induced diabetes in mice. Arch Virol 153:1223-1231, 2008.
9. Nagafuchi S, Kudoh J, Shimizu N, et al. Recurrent herpes simplex virus (HSV) infection in a patient with APECED associated with AIRE gene mutations.
J Intern Med 261:605-610, 2007.
10. Nagafuchi S, Umene K, Yamanaka F, Oohashi S, Shindo M, Kurisaki H, Kudoh J, Shimizu N, Hara T, Harada M. Recurrent herpes simplex virus (HSV) infection in a patient with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy associated with L29P and IVS9-1G>C compound heterozygous autoimmune regulator (AIRE) gene mutations. J Intern Med 261:605-610, 2007
11. Sakai Y, Maruyama T, Katsuta H, Kogawa K, Akashi T, Izumi K, Tominaga H, Kono S, Nagafuci S, Harata M. Patients with dilated cardiomyopathy possess insulin resistance independently of cardiac dysfunction or serum tumor necrosis factor-alpha.
Int Heart J 47(6):877-887, 2006.
12. Cavadini P, Vermi W, Facchetti F, Fontana S, Nagafuchi S, Mazzolari E, et al. AIRE deficiency in thymus of 2 patients with Omenn syndrome.
J Clin Invest 115:728-32, 2005.
13. Akashi T, Minagawa H, Katsuta H, Harada M, Nagafuchi S. Retrograde intrafamilial transmission of primary herpes simplex virus type 1 infection. Am J Med 113:79-80, 2002.
14. Kondo S, Iwata I, Anzai K, Akashi T, Wakana S, Ohkubo K, Ono J, Watanabe T, Niho Y, Nagafuchi S. Suppression of insulitis and diabetes in B cell deficient mice treated with streptozocin. Int Immunol 12:1075-1083, 2000.
15. Iwata I, Nagafuchi S, Nakashima H, Kondo S, Koga T, Yokogawa Y, Akashi T, Shibuya T, Umeno Y, Okeda T, Shibata S, Kono S, Yasunami M, Ohkubo H, Niho Y: Association of polymorphism in the NeuroD/BETA2 gene with type 1 diabetes in the Japanese. Diabetes 48: 416-419, 1999
16. Nagafuchi S, Katsuta H, Kogawa K, Akashi T, Kondo S, Sakai Y, Tsukiyama T,Kitamura D, Niho Y, Watanabe T: Establishment of an embryonic stem (ES) cell line derived from a non-obese diabetic (NOD) mouse: In vivo differentiation into lymphocytes and potential for germ line transmission. FEBS Lett 455:101-104, 1999.
17. Anzai K, Nagafuchi S, Kikuchi M.Niho Y, Ono J: β2-Glycoprotein 1 -dependent and -independent anticardiolipin antibody in NOD mice. Clin exp Immunol 111:173-180, 1998
18. Akashi T, Nagafuchi S, Anzai K, Kondo S, et al. Direct evidence for the contribution of B cells to the progression of insulitis and the development of diabetes in non-obese diabetic mice. Int Immunol 9:1159-1164, 1997.
19. Nagafuchi S, Anzai K, Kazawa K, Yokogawa Y, Okeda T, Nose Y, Niho T, Sakata T,
Takaki R. The impact of a color-classified HbA1c graph for self-monitoring and self
adjustment of long-term glycemic control. Diabetes Care16(10):1408-1409, 1993.
20. Nagafuchi S, Kashiwagi S, Okada K, Anzai K, Nakamura M, Nishimura Y, Sasazuki T, Niho Y. Reversal of Nonresponders and Postexposure Prophylaxis by Intradermal Hepatitis B Vaccination in Japanese Medical Personnel. JAMA 265:2679-2683, 1991.
21. Nagafuchi S, Kashiwagi S. Reversal by intradermal hepatitis B vaccination of unresponsiveness to HBsAg. Lancet II:1522-1523, 1987.
22. Kounoue E, Nagafuchi S, Nakamura M, Nakano S, Koga T, Nakayama M, Mitsuyama M, Niho Y, Takaki R. Encephalomyocarditis (EMC) virus-induced diabetes mellitus prevented by Corynebacterium parvum in mice. Experientia 43:430-431, 1987.
23. Sugihara J, Imamura T, Nagafuchi S, Bonavantura J, Bonaventura D, Cashon R. Hemoglobin Rahere, a human hemoglobin variant with amino acid substitution at the 2,3-diphosphoglycerate binding site.
J Clin Invest 76:1169-1173, 1985.
24. Nakamura M, Nagafuchi S, Yamaguchi K, Takaki R. The role of thymic immunity and insulitis in the development of streptozocin induced diabetes in mice. Diabetes 33:894-900, 1984.
25. Hayashida I, Nagafuchi S, Hayashi Y, Kino Y, Mori R, Oda H, Ohtomo N, and Tashiro A: Mechanism of antibody mediated protection against herpes simplex virus infection in mice: Requirement of Fc portion of antibody. Microbiol Immunol 26:497-509,1982.
26. Nagafuchi S, Oda H, Mori R Taniguchi T.　Mechanism of acquired resistance to herpes simplex virus infection as studied in nude mice. J Gen Virol 44:715-723, 1979.

症例報告
1. Nagafuchi S, Mine K, Anzai K et al. Excellent blood glucose levels for 5 years with well maintained insulin secretion by a once-weekly injection of dulaglutide:GPL-1RA alone in a patient with type 2 diabetes mellitus. Austin J Endocrinol Diab 10(1):1099, 2023.
2. Kashiwagi K, Nagafuchi S, Sekiguchi N, Yamagata A, Iwata I, Furuya H, Kato K, Niho Y. Troglitazone not only reduced insulin resistance but also improved myotonia in a patient with myotonic dystrophy. Europ Neurol 41:171-172, 1999.
3. Nagafuchi S, et al. Eosinophilia after intradermal hepatitis B vaccination.
Lancet 342:998, 1993.
4. Fujisaki T, Nagafuchi S, Okamura T. Gamma-Interferon for severe chronic active Epstein-Barr Virus. Ann Intern Med 118:474-475, 1993.
5. Fujisaki T, Nagafuchi S, et al. Malignant histiocytosis in a patient with chronic active Epstein-Barr virus infection. Lancet 340:1168-1169, 1992.
6. Akashi K, Ishimaru T, Tsuda Y, Nagafuchi S, Itaya R, Hayashi J, Kawachi Y, Sawae Y, Niho Y. Purulent pericarditis caused by Streptococcus Milleri. Arch Intern Med 148:446-2447, 1988.

総説　
1. Nagafuchi S, Mine K, Perveen R, Mori H, Anzai K, Takahashi H. Significance of the tyrosine kinase 2 gene in both type 1 and type 2 diabetes. BMJ Open Diabetes Res Care in press.
2. Nagafuchi S. Regulation of Viral Infection in Diabetes. (as Guest Editor of Biology 10(6) issue) Biology 10(6):529, 2021.
3. Mine K, Nagafuchi S, Mori H, Takahashi H, Anzai K. SARS-CoV-2 infection and pancreatic β-cell failure. Biology 11(1):22, 2021.
4. Mine K, Yoshikai Y, Takahashi H, Mori H, Anzai K, Nagafuchi S. Genetic susceptibility of the host in virus-induced diabetes. Microorganisms 8(8):1133, 2020.
5. Nagafuchi S, Mine K, Takahashi H, Anzai K, Yoshikai Y. Viruses with masked pathogenicity and genetically susceptible host-How to discover potentially pathogenic viruses. J Med Virol 91(8):1365-1367, 2019, 8月号表紙.
6. Mine K, Takahashi H, Nagafuchi S. Model animal mimicking human virus-induced diabetes. EBioMedicine 32:8, 2018.
7. Nagafuchi S,. Virus-induced diabetes: Koch’s Postulate fulfillable? Int J Diabetes Clin Diagn　3:115,　2016.
8. Nagafuchi S, Toniolo A. Viral Diabets:Virus diabetogenicity and host susceptibility.
Immunoendocrinol 2:1026, 2015,
9._Nagafuchi S, Katsuta H, Anzai K. Rituximab, B-lymphocyte depletion, and beta-cell function.
N Engl J Med 363(8):761. 2010.

著書
1. Nagafuchi S, Katsuta H, Kurisaki H. Encephalomyocarditis virus.　Taylor K, Hyöty H, Toniolo A, Zuckerman A. Editors. Diabetes and Viruses　Springer Science Pub. pp.37-48, 2013.
2. 永淵正法（編集代表） 糖尿病治療ハンドブック　医学出版　2010

特許
1. 永淵正法.　糖化ヘモグロビン値書き込みグラフ. 実用新案　　1989.
2. 永淵正法. マウス膵β細胞特異的ヒトコクサッキーアデノウイルス受容体(hCAR)発現
トランスジェニックマウス. （日本、および米国へ特許申請中）